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Preliminary Research on Estrogen-like Effect of Murraya exotica( L. ) and the Chondroprotection Activity

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【作者】 Fahui ZENGHaiqing LIULinfu LIRui ZHANGLonghuo WU

【Author】 Fahui ZENG;Haiqing LIU;Linfu LI;Rui ZHANG;Longhuo WU;College of Pharmacy,Gannan Medical University;

【机构】 College of Pharmacy,Gannan Medical University

【摘要】 [Objective]To study on estrogen-like effect of Murraya exotica( L.) and the chondroprotection activity. [Methods]60 rats were randomly divided into 6 groups,10 rats each group. They were sham operation group,ovariectomized group,nilestriol group,low-,medium-, and high-dosage Murraya exotica( L.) group. Ovariectomized rats were duplicated as a model,0. 8% CMC- Na was administrated to rats in sham operation group and ovariectomized group after operation. Rats in nilestriol group was administrated according to the dose of 0. 5 mg / kg. After eight weeks of administration,the weight of uterus and the contents of estradiol in the serum were determined,the contents of hyaluronic acid in the serum and synovia were also determined. [Results]The weights of uterus,the content of estradiol in the serum,and the hyaluronic acid in the synovia in rats of different dosages of Murraya exotica( L.) group were much lower than those in rats of nilestriol group,but higher than those in rats of ovariectomized group. They were positively related to the dosages of Murraya exotica( L.) and showed significant difference. Conversely,the hyaluronic acid in the serum exhibited negatively related to those dosages significantly. [Conclusions]With estrogenlike activity,Murraya exotica( L.) could protect cartilago articularis by regulating the level of hyaluronic acid.

【基金】 Science and Technology Project of Jiangxi Education Depart-ment(GJJ13669);Initial Funding for Talent Introduction of Gannan Medical University(NO.201102);Colonel-level Topics of Gannan Medical University(YB201012)
  • 【分类号】S567.239
  • 【下载频次】11
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