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The Efficacy Trials and Researches of Codonopsis Polysaccharide on Improving Digestive Functions

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【作者】 Fangli MAXuemei SHENJun SHIMing LIANGWeitong Xu

【Author】 Fangli MA;Xuemei SHEN;Jun SHI;Ming LIANG;Weitong Xu;Infinitus(China) Co.,Ltd.;Department of Traditional Chinese Medicine Guangdong Pharmaceutical University;

【机构】 Infinitus(China) Co.,Ltd.Department of Traditional Chinese Medicine Guangdong Pharmaceutical University

【摘要】 [Objective]To explore the effects of codonopsis polysaccharide on mice and rats’ digestive functions. [Methods]Male rats were randomly divided into blank group,positive control group( sijunzi decoction concentrated solution,1. 5 g / kg),low-dosage group( 50 mg / kg),medium-dosage group( 100 mg / kg) and high-dosage group( 200 mg / kg),and were fed according to dose of 0. 01 mL / kg. Everyday fed rats with drugs by intragastric administration for one time,last for 30 days and then observed body weight,weight gain,food intake dose and food utilization rate and measured pepsin activity and amount of pepsin secretion; Female mice were randomly divided into blank group,positive control group( sijunzi decoction concentrated solution,3 g / kg),low-dosage group( 100 mg / kg),middle-dosage group( 200 mg / kg) and high-dosage group( 400 mg / kg),and were fed according to dose of 0. 01 mL / kg. Everyday fed mice with drugs by intragastric administration for one time, last for 20 days and conducted small intestine motion testing,measured propulsive rate of active carbon powder in mice’s small intestines and observed the pathological section of gastrointestinal tract in rats. [Results]Codonopsis pilosula( 200,400 mg / kg) can improve small intestine propulsion decrease induced by compound diphenoxylate and reduce gastric secretion in rats. Codonopsis pilosula( 400 mg / kg) can significantly increase the amount of pepsin secretion. Low,medium and high dosage can significantly enhance animal appetite and food intake and increase the animal body weight. The observation of the pathological section of gastrointestinal tract in rats confirmed that codonopsis pilosula could improve gastrointestinal physiology,increase the thickness of gastric mucosal and gastric wall,promote the growth of micro intestinal villus in duodenum and jejunum. [Conclusions] Codonopsis pilosula has healthcare function of improving digestion.

【基金】 Funded by Science and Technology Plan of Guangdong Province(Project 2011B030500004)
  • 【分类号】S567.51
  • 【被引频次】2
  • 【下载频次】37
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