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Effect of MORINDAE OFFICINALIS Extract on the Behavior and Zymology of Senile Dementia Model Rats

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【作者】 Jiawei MIAOYuling FENGGuoqi LAIShuangshuang JIAJing LI

【Author】 Jiawei MIAO;Yuling FENG;Guoqi LAI;Shuangshuang JIA;Jing LI;Chongqing Three Gorges Medical College;Chongqing Medical University;Chongqing Health Center for Women and Children;

【机构】 Chongqing Three Gorges Medical CollegeChongqing Medical UniversityChongqing Health Center for Women and Children

【摘要】 [Objective]To study the effect of MORINDAE OFFICINALIS extract on the behavior and zymology of senile dementia rat model. [Methods]Senile dementia rat model was prepared by intraperitoneal injection of D-galactose( 120 mg/kg) and sodium nitrite( 90 mg/kg) for 30 d. 60 rats were divided into 6 groups,normal control group,model group,nimodipine group,high-dosage group of aqueous extract of MORINDAE OFFICINALIS,medium-dosage group of aqueous extract of MORINDAE OFFICINALIS and low-dosage of aqueous extract of MORINDAE OFFICINALIS. The learning and memory ability was measured by rat step-down test. The activities of SOD,MDA and MAO-B were determined. The expression of MAO-B mRNA was determined by RT-PCR. [Results]After intraperitoneal injection of MORINDAE OFFICINALIS extract,the learning and memory abilities of model rats increased. The biochemical criterion of SOD,MDA and MAO-B was improved. The expression level of MAO-B mRNA decreased significantly. [Conclusions] Extract of MORINDAE OFFICINALIS could protect acute aging model rats at certain degree.

【基金】 The Medical Scientific Research Project of Chongqing Municipal Health Bureau(No:2012-096);Major Project of Educational Reform of Chongqing Higher Education(No:132128,133309);Science and Technology Planning Project of Wanzhou District(No:201203055)
【所属期刊栏目】 Pharmacological and Toxicological Analyses (2014年02期)
  • 【分类号】S567.19
  • 【下载频次】13
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