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Anti-oxidative Activity of Flavonoids from Cherry Leaves in Vitro

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【作者】 Shan ZHENGFeng ZHAOZucheng LIYuanfang WANG

【Author】 Shan ZHENG;Feng ZHAO;Zucheng LI;Yuanfang WANG;Binzhou Medical University;Yantai Affiliated Hospital of Binzhou Medical University;

【机构】 Binzhou Medical UniversityYantai Affiliated Hospital of Binzhou Medical University

【摘要】 [Objective] This study was undertaken to extract flavonoids from cherry leaves and to investigate the anti-oxidative activity in vitro. [Methods]The scavenging action on OH·and O-2·and its inhibiting effect on oxidative hemolysis of erythrocyte induced by H2O2and lipid peroxidation of hepatic tissue in mice were investigated in vitro. [Results] The flavonoids showed concentration-dependent scavenging effect on OH·and O-2·. The flavonoids also showed remarkable inhibiting effects on oxidative hemolysis of erythrocyte in mice induced by H2O2. When the final concentration of the flavonoids reached 30%,the inhibition rate was 74. 13%. It could inhibit lipid peroxidation of hepatic tissue in mice induced by vitamin C with low concentration and ferrous sulfate. And the inhibiting effect was concentration-dependent.When the final concentration of the flavonoids reached 30%,the inhibition rate was 68. 33%. [Conclusions]The total flavonoids from cherry leaf have concentration-dependent antioxidant activity in vitro.

【基金】 Shandong Natural Science Funds(ZR2011HM059);Yantai Scientific and Technological Advance Project(2009168);Undergraduates’ Technical Innovative Project of Binzhou Medical University(BY2010DKCX60)
【所属期刊栏目】 Pharmacological and Toxicological Analyses (2014年05期)
  • 【分类号】R284
  • 【下载频次】25
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