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Inhibitory Effects of Polyphenols from Pinus koraiensis Seed Scale on the Proliferation of Human Cancer Cells in Vitro

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【作者】 Qun FUMinghui XUXiaotang GAOZhenyu WANG

【Author】 Qun FU;Minghui XU;Xiaotang GAO;Zhenyu WANG;School of Forestry,Northeast Forestry University;School of Food Science and Engineering,Herbin Institute of Technology;

【机构】 School of Forestry,Northeast Forestry UniversitySchool of Food Science and Engineering,Herbin Institute of Technology

【摘要】 [Objective] To research on the inhibitory effects of polyphenols from Pinus koraiensis seed scale on the proliferation of human cancer cells in vitro. [Methods] Polyphenols from Pinus koraiensis seed scale were prepared into extracting solutions at different concentrations. Suspension cultures of five tumor cells were processed,which were lung carcinoma cell A549,human bone marrow neuroblastoma cell SH-SY5 Y,human skin cancer cell A375,human hepatocarcinoma cell HepG-2 and human ovarian cancer cell SKOV3. Inhibitory rate of cell proliferation in vitro was detected by MTT method. [Results] P. koraiensis polyphenols had relatively good inhibitory effects on A549,showing certain correlation with time or concentration. The inhibitory rare was the optimal when the concentration of P. koraiensis polyphenols was0. 4 mg / mL. Under this concentration,the inhibitory rate of extracting solution of P. koraiensis polyphenols reached 55% on lung carcinoma cell A549. P. koraiensis polyphenols showed no significant inhibitory effects on SH-SY5 Y,A375,HepG 2 or SKOV3. [Conclusions] P. koraiensis polyphenols had inhibitory effects on lung carcinoma cells.

【基金】 Supported by the Surface Project of National Natural Science Foundation of China(C160131170510)
【所属期刊栏目】 Pharmacological and Toxicological Analyses (2014年09期)
  • 【分类号】R285.6
  • 【下载频次】16
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