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Study about the Antioxidant Protective Action of Gallate on Nerve Cell

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【作者】 Wei TIANYuting BIQilong ZHOUYanhong XUEMin QIUFeijun DANShiping LIU

【Author】 Wei TIAN;Yuting BI;Qilong ZHOU;Yanhong XUE;Min QIU;Feijun DAN;Shiping LIU;Chemistry and Life Science College of China Three Gorges University;

【机构】 Chemistry and Life Science College of China Three Gorges University

【摘要】 To compare the cytotoxicity of different gallate compounds and analyze the effect of gallate compounds at different concentrations on the growth of nerve cell under oxidative stress induced by hydrogen peroxide. Results indicated that Ethyl gallate,Propyl gallate and Isoamyl Gallate could effectively increase the survival rate of SH-SY5 Y cell damaged by hydrogen peroxide which suggested that they had protection effect on nerve cell with oxidative stress injury. Particularly,Methyl 3,4-dimethoxy-5-hydroxybenzoate separated from Myricaria laxiflora,threatened plant in the Three Gorges,had better antioxidant protective effect than Propyl gallate which indicated that it could be developed and used as a kind of potential drug treating neurodegenerative disease.

【基金】 National Natural Science Foundation of China(31270389);Natural Science Research Project of Hubei Education Department(D20121301)
【所属期刊栏目】 Pharmacological and Toxicological Analyses (2015年Z1期)
  • 【分类号】R741
  • 【下载频次】26
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