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Immunomodulatory Effects of Yupingfeng Polysaccharides on Immunosuppressed Mice

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【作者】 Hong YANGHua DENGJipei ZHANGFang CHENWenjun PUJiedan LIAOKe MA

【Author】 Hong YANG;Hua DENG;Jipei ZHANG;Fang CHEN;Wenjun PU;Jiedan LIAO;Ke MA;College of Life Science,Foshan University;

【机构】 College of Life Science,Foshan University

【摘要】 [Objective] To discuss the protection and regulatory effects of Yupingfeng polysaccharides on immunosuppressed mice. [Methods] The immunosuppressive mice model was established by 80 mg / kg cyclophosphamide. The spleen index,spleen lymphocyte proliferation capability,serum hemolysin antibody generation and serum IL-2 level of mice were researched,so as to observe the effects of Yupingfeng polysaccharides at different dosages( 100,200,400 mg / kg). [Results] Yupingfeng polysaccharides enhanced the spleen index of immunosuppressed mice,improved the proliferation capability of spleen lymphocyte,promoted the generation of serum hemolysin antibody in normal mice,and protected against the secretion reduction of serum hemolysin antibody induced by cyclophosphamide. Besides,Yupingfeng polysaccharides enhanced the IL-2 levels in serum of both immunosuppressed and normal mice,especially that the middle-and low-dosage groups had relatively significant effects.[Conclusions] Yupingfeng polysaccharides protected against the immunosuppression of mice induced by cyclophosphamide,enhanced the immune function and protected the spleen function of mice.

【基金】 Supported by the Natural Science Foundation of Guangdong Province(S2013010012191);the Science and Technology Planning Project of Guangdong Province(2009B020307004)
【所属期刊栏目】 Pharmacological and Toxicological Analyses (2015年Z1期)
  • 【分类号】R285.5
  • 【下载频次】55
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