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Sduty on the Anti- inflammatory Mechanism of Gentiana rigescens

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【作者】 Xin YULilan OUMeiping RENDan ZHANG

【Author】 Xin YU;Lilan OU;Meiping REN;Dan ZHANG;Luzhou Medical College;

【机构】 Luzhou Medical College

【摘要】 [Objective] To study the anti-inflammatory mechanism of Gentiana rigescens. [Methods] Determinations of malondialdehyde( MDA) and prostaglandin E2( PGE2),tumor necrosis factor alpha( TNF alpha) and interleukin 1 beta( IL-1 beta) content in rat chest percolate and nitric oxide( NO),PGE2,TNF alpha,beta,IL-1 and MDA content in rat lung tissue were conducted to investigate the anti-inflammatory mechanism.[Results] Compared with 5% twain- 80,ethanol extract group( 6 g / kg,crude drug amount) and water parts group( 6 g/kg,crude drug amount) of Gentiana rigescens could inhibit improvement of NO,MDA,PGE2,TNF-α and IL-1β content in chest percolate( P < 0. 01) and NO,MDA,PGE2,TNF-α and IL-1β content in lung tissue( P < 0. 01). [Conclusion]The anti-inflammatory mechanism of Gentiana rigescens may be related to the effects on generating of inflammatory mediators and antioxidant effect.

【基金】 Supported by Youth Fund Luzhou Medical School in 2012(2012QN-53)
【所属期刊栏目】 Pharmacological and Toxicological Analyses (2015年Z1期)
  • 【分类号】R285
  • 【被引频次】1
  • 【下载频次】12
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