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Protective Effects of Total Flavonoids in Polygonum perfoliatum L.on the Acute Liver Injury of Mice Induced by CCl4 and Its Action Mechanism

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【作者】 Mingli ZHONGYa GAOYifei CHENKefeng ZHANG

【Author】 Mingli ZHONG;Ya GAO;Yifei CHEN;Kefeng ZHANG;Guilin Medical University;

【机构】 Guilin Medical University

【摘要】 [Objective] To research on the protective effects of total flavonoids in Polygonum perfoliatum L. on the acute liver injury of mice induced by CCl4 and its action mechanism. [Methods]Flavonoids were extracted from P. perfoliatum by chemical method. Acute liver injury model of mice was established by intraperitoneal injection of CCl4 peanut oil. The biochemical indexes of ALT,AST,TNF-α,IL-1β and IL-6in mice serum were detected. Histopathological examination of liver tissue was carried out. [Results] Flavonoids in P. perfoliatum restricted the ALT,AST,TNF-α,IL-1β and IL-6 activities in mice serum with acute liver injury( P < 0. 01,P < 0. 05). Results of histopathological examination also showed that flavonoids significantly improved the liver injury of mice. [Conclusions] Flavonoids in P. perfoliatum showed protective effects of acute liver injury of mice induced by CCl4; and its mechanism might be related with anti-inflammation.

【基金】 Supported by the National Natural Science Foundation of China(81460602)
【所属期刊栏目】 Pharmacological and Toxicological Analyses (2015年Z2期)
  • 【分类号】R285.5
  • 【被引频次】10
  • 【下载频次】66
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