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The Acute Toxicity and Subchronic Toxicity Test of Zhuqin Extract

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【作者】 Guoshu LIUFUZhaorong ZHUJuan LIUMaixun ZHU

【Author】 Guoshu LIUFU;Zhaorong ZHU;Juan LIU;Maixun ZHU;Traditional Chinese Medicine Innovation Research Laboratory,Department of Veterinary Medicine,Southwest University;

【机构】 Traditional Chinese Medicine Innovation Research Laboratory,Department of Veterinary Medicine,Southwest University

【摘要】 [Objective] To investigate the safety of compound Zhuqin extract.[Methods]In acute toxicity test,mice in test group were given compound Zhuqin extract( i. g.) by gavage,the dosage of which was 0. 8,0. 6,0. 45,0. 35 g /20 g,to determine the median lethal dose of compound Zhuqin extract( LD50). In maximum tolerance experiment,mice in test group were given compound Zhuqin extract( i. g.) by gavage,the dosage of which was 0. 5 g /20 g,to determine the maximum tolerance dose( MTD); In the sub- chronic toxicity test,rats in test group were given compound Zhuqin extract( i. g.) by gavage for 30 d,the dosage of which was 2. 0,1. 5,1. 0 g /200 g,and normal saline negative control group was set. Clinic condition of rat was observed everyday,hematology,blood biochemistry,anatomy,organ index and organization pathological observation were conducted after test.[Results]The acute toxicity test failed to detect median lethal dose of compound Zhuqin extract; the weight differences were not significant( P > 0. 05); some blood biochemical criterion and blood routine index had significant differences( 0. 01 < P < 0. 05),and some indexes had extremely differences( P < 0. 01); organ index,necropsy and histopathology had abnormalities.[Conclusions] Compound Zhuqin extract was safe and reliable.

【基金】 Supported by the Scientific Research Special Project of Public Welfare Industry(Agriculture)(201303040);Special Project of Scientific Research Groundwork(2013FY110600)
【所属期刊栏目】 Pharmacological and Toxicological Analyses (2015年Z2期)
  • 【分类号】R285
  • 【被引频次】2
  • 【下载频次】51
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