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Studies on Anti-inflammatory Effects and Mechanism of Phellodendri Chinensis Cortex

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【作者】 Lilan OUXin YUChun ZHANGYe ZHU

【Author】 Lilan OU;Xin YU;Chun ZHANG;Ye ZHU;Department of Pharmacy,Southwest Medical University;

【机构】 Department of Pharmacy,Southwest Medical University

【摘要】 [Objective] To observe the anti-inflammatory effects of alcohol extract of Phellodendri Chinensis Corte and explore its mechanism.[Method]ICR mice were divided into 5 groups randomly,namely the model group,dexameathone group( 0. 01 g/kg),alcohol extraction of Phellodendri Chinensis Corte groups( 9. 0,4. 5 and 3. 0 g / kg). Each drug was administrated to the mice orally once a day for 15 days. After30 min of the last administration,its anti-inflammatory effect was observed by the method of acetic acid-induced permeability accentuation. SD rats were divided into 5 groups randomly,namely the model group,dexameathone group( 0. 01 g / kg),alcohol extraction of Phellodendri Chinensis Corte groups( 9. 0,4. 5 and 3. 0 g / kg). Each drug was administrated to the rats orally once a day for 15 days. After 30 min of the last administration,the rat model of carrageenan-induced acute pleurisy was also selected to observe the anti-inflamatory effect. The anti-inflammatory mechanism was investigated by detecting the contents of prostaglandins( PGE2),tumor necrosis factor-alpha( TNF-α),and interleukin-1β( IL-1β) in the exudates,and the contents of TNF-α,IL-1β,and malondialdehyde( MDA) in the lung tissue were also detected.[Result]Compared with the model group,the alcohol extract of Phellodendri Chinensis Corte groups( 9. 0 and 4. 5 g/kg) had significant inhibitory effects on the acetic acid-induced permeability accentuation in the mice,while the alcohol extract of Phellodendri Chinensis Corte groups( 9. 0 and 4. 5g / kg) significantly reduced the levels of PGE2,TNF-α and IL-1β in the exudates( P <0. 05),while the high-dose alcohol extract of Phellodendri Chinensis Corte group( 9. 0 g / kg) also reduced the contents of TNF-α,IL-1β and MDA in the lung tissue of the carrageenan treated rats( P < 0. 01),and the moderate-dose alcohol extract of Phellodendri Chinensis Corte group( 4. 5 g / kg) decreased the content of IL-1β in the lung tissue( P < 0. 01). [Conclusion]The alcohol extraction of Phellodendri Chinensis Corte possesses significant anti-inflammatory effects,which can be related to the inhibition of generation of the inflammatory mediators and its antioxidation.

【所属期刊栏目】 Pharmacological and Toxicological Analyses (2016年Z2期)
  • 【分类号】R285.5
  • 【被引频次】1
  • 【下载频次】10
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