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Effects of Quercetin Liposomes on Oxidative Stress and Expression of TGF- β1 in Kidney of Diabetic Rats

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【作者】 Kaimei ZHUChaohao GUJing LILixia TANGYourui XUShengjiu GU

【Author】 Kaimei ZHU;Chaohao GU;Jing LI;Lixia TANG;Yourui XU;Shengjiu GU;Guilin Medical University;The Second Affiliated Hospital of Guilin Medical University;Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization;

【机构】 Guilin Medical UniversityThe Second Affiliated Hospital of Guilin Medical UniversityGuangxi Key Laboratory of Functional Phytochemicals Research and Utilization

【摘要】 [Objective] To observe the effects of different doses of quercetin liposomes( LQ) on oxidative stress and expression of TGF-β1 in kidney of diabetic rats. [Methods]The model of type 2 diabetic nephropathy rats was established by being fed on high-sugar and high-fat diet combined with intraperitoneal injection of streptozotocin( STZ). Then type 2 diabetic rats were randomly divided into six groups: diabetic model group( group DM),low level of LQ group( group LQ-L),medium level of LQ group( group LQ-M),high level of LQ group( group LQH),positive control group( group aminoguanidine,AG) and control group( group N). After 8 weeks,the serum levels of total cholesterol( TC),triglycerides( TG),superoxide dismutase( SOD),malondialdehyde( MDA),glutathione peroxidase( GSH-Px) were measured by biochemical methods. Immunohistochemistry and RT-PCR were used to detect expression of TGF-β1 gene and protein in kidney cortex of diabetic rats. [Results]Compared with the group N,the serum levels of SOD and GSH-Px decreased significantly in group DM,while the serum levels of TC,TG and MDA increased significantly and the expression levels of TGF-β1 gene and protein in kidney tissue increased significantly.Compared with the group DM,in each dose group of LQ have improved the above indicators to some extent and the group LQ-M was more obvious than others. [Conclusions] LQ reduces the blood lipid levels,protects antioxidant activity,inhibits lipid peroxidation of DM rats,and then reduces expression of TGF-β1 gene and protein in kidney cortex.

【基金】 Supported by Guangxi Plan Item for Science Research and Technology Development(Guikeneng 159832-46,Guikehe 14123001-22);Guilin Plan Item for Science Research and Technology Development(20150102-8,20150102-7,20150102-6,20140105-11,20140122-5,20140105-5);Open Fund for Guangxi Key Laboratory of Plant Function Material Research and Utilization(FPRU2015-5)
【所属期刊栏目】 Pharmacological and Toxicological Analyses (2016年Z4期)
  • 【分类号】R285.5
  • 【被引频次】1
  • 【下载频次】43
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