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Protective Effect of Total Flavonoids Extracted from Polygonum knotweed L. on Mice with Liver Injury Induced by Antituberculosis Drugs

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【作者】 Ya GAOSimao HUANGHoukang CAOKefeng ZHANG

【Author】 Ya GAO;Simao HUANG;Houkang CAO;Kefeng ZHANG;Guilin Medical University;

【机构】 Guilin Medical University

【摘要】 [Objectives] To study the therapeutic effect and mechanism of total flavonoids extracted from Polygonum knotweed L. on mice with liver injury induced by antituberculosis drugs. [Methods]60 mice were randomly divided into six groups,namely normal control group,model group,glucurolactone group( 200 mg / kg),high-dose( 600 mg / kg),medium-dose( 300 mg / kg),and low-dose( 150 mg / kg) groups of total flavonoids extracted from P. knotweed. Except for the mice in the normal control group,the mice in the other groups were given intragastric administration of isoniazid and rifampicin( 100 mg / kg) to induce liver injury model,and were simultaneously treated with corresponding agents once a day for 30 d. On the 30 thday,the blood and liver tissue were sampled,and ALT,AST,MDA,SOD and GSH-PX content were detected by biochemical methods; pathological changes of liver tissue were observed after HE staining. [Results]Compared with the model group,ALT,AST and MDA content in the serum of the mice with liver injury increased,while SOD and GSH-PX content decreased in high-dose( 600 mg / kg) and medium-dose( 300 mg / kg) groups of total flavonoids extracted from P. knotweed( P < 0. 05 or P < 0. 01,and the pathological changes of liver tissue of the mice were alleviated at the same time. However,the low-dose( 150 mg / kg) group of total flavonoids extracted from P. knotweed had no significant effects on liver injury caused by antituberculosis drugs. [Conclusions]Total flavonoids extracted from P.knotweed has an obvious therapeutic effect on liver injury induced by antituberculosis drugs,and the mechanism may be associated with its antioxidative stress and inhibition of lipid peroxidation.

【基金】 Supported by National Natural Science Foundation of China(81460602)
【所属期刊栏目】 Pharmacological and Toxicological Analyses (2016年Z6期)
  • 【分类号】R285.5
  • 【被引频次】1
  • 【下载频次】34
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