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Clustering Analysis of Tissues and Organs of Tibetan Medicines Renqing Mangjue Compatible with Zuota

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【作者】 Bochao LIBo LIYun TENGChunlin LIUYuan LIU

【Author】 Bochao LI;Bo LI;Yun TENG;Chunlin LIU;Yuan LIU;College of Pharmacy,Southwest University for Nationalities;Ethnic Medicine Institute,Southwest University for Nationalities;

【机构】 College of Pharmacy,Southwest University for NationalitiesEthnic Medicine Institute,Southwest University for Nationalities

【摘要】 [Objectives] By clustering analysis of tissue distribution data of brucine and strychnine in gastric ulcer model rat,the impact of Zuota on tissue distribution of basic components was studied. [Methods] Based on system clustering method of SPSS19. 0 statistical analysis software,using inter-group join method and squared Euclidean distance,brucine and strychnine contents of different tissues and organs in nonZuota group and Zuota group were taken as characteristic variables for clustering analysis,and phylogenetic tree was established. [Results]When clustering distance was 1,( i) taking brucine content as the index,there were three kinds of convergences in non-Zuota group. A1class: skin,liver,epididymis and jejunum; A2 class: brain and uterus; A3 class: testis and muscle. Brucine contents of the three classes showed as A1 < A2 < A3. There were two classes of convergences in Zuota group. B1 class: jejunum,epididymis,kidney,brain,skin and uterus; B2 class: muscle and( bottom) submandibular gland. Brucine contents of the two classes showed as B1 < B2.( ii) Taking strychnine content as the index,there were three classes of convergences in non-Zuota group. C1 class: muscle,testicle and oarium; C2 class: heart and lung; C3 class: uterus and liver. Strychnine contents of the three classes showed as C3 < C1 < C2. There were two kinds of convergences in Zuota group. D1 class: kidney and heart; D2 class: brain tissue and uterus. Strychnine contents of the two classes showed as D1 > D2. [Conclusions]When clustering distance was 1,low-content tissues and organs firstly clustered,and its toxicological effect( or pharmacodynamic action) was insignificant,and this kind of tissues and organs were relatively safe. A1 class and A2 class in Zuota group were merged into B1 class,in which liver was replaced by kidney. It illustrated that Zuota could decline the toxicity of kidney,and enlarged the safe action range of brucine. Kidney and heart in C2 class were clustered into D1 class,and average strychnine content in C2 class was higher than that of D1 class. It could be deduced that Zuota had the effect of protecting heart.

【基金】 Supported by National Natural Foundation(81173653);Postgraduate Innovation Type of Scientific Research Item of Southwest University for Nationalities(CX2016SZ043)
【所属期刊栏目】 Pharmacological and Toxicological Analyses (2016年Z6期)
  • 【分类号】R29
  • 【下载频次】10
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