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The Effects of Alcohol and Water Extracts of Allium wallichii Kunth on Transplanted Hepatoma,Lung Cancer and Breast Cancer of Mice

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【作者】 Fenglin WANGYunzhang XUPanpan LIULimin LIYuan LIU

【Author】 Fenglin WANG;Yunzhang XU;Panpan LIU;Limin LI;Yuan LIU;College of Pharmacy,Southwest University for Nationalities;Institute of Botany,Chinese Academy of Sciences;Bijiang District Tongren City Medium Occupation School;Sichuan Academy of Chinese Medicine Sciences;Ethnic Medicine Institute,Southwest University for Nationalities;

【机构】 College of Pharmacy,Southwest University for NationalitiesInstitute of Botany,Chinese Academy of SciencesBijiang District Tongren City Medium Occupation SchoolSichuan Academy of Chinese Medicine SciencesEthnic Medicine Institute,Southwest University for Nationalities

【摘要】 [Objectives] To study the anti-tumor effects of alcohol and water extracts of A. wallichii Kunth. [Methods]In vivo experiment of transplanted tumors was employed to observe the effects of different solvent extracts of A. wallichii Kunth on transplanted S180 sarcoma and transplanted H22 hepatoma of KM mice,transplanted Lewis lung cancer of C57 BL mice and transplanted EMT-6 breast cancer of BALB / C mice. 20 g / kg of different solvent extracts of A. wallichii Kunth were injected in mice with different types of transplanted tumors,while the blank control group was treated with same-dosage normal saline. After 11 days,the mice were killed,and the inhibitory rate of tumor was calculated. [Results] Compared with blank control group,the tumor weight of medicated group decreased obviously( P < 0. 05 or P < 0. 01),and the group treated with the extracts of roots and rhizomes,and leaves of A. wallichii Kunth had more obvious decrease effect in the same dosage( P < 0. 05 or P < 0. 01). [Conclusions] Different solvent extracts of A. wallichii Kunth showed anti-tumor effect,especially the extracts of roots and rhizomes,leaves of A. wallichii Kunth showed the obvious effect.

【基金】 Supported by National Science and Technology Support Plan(2015BAC-05B02);Sichuan Science and Technology Support Plan(2015SZ0034);Education and Teaching Research and Innovation Item of Southwest University for Nationalities(2015)
【所属期刊栏目】 Pharmacological and Toxicological Analyses (2016年Z6期)
  • 【分类号】R285.5
  • 【下载频次】15
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