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Preparation and Evaluations of Ibuprofen Thermosensitive in situ Gel

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【作者】 Miao YUShangcong HANJialing DAIJiao LIUChen WEIYitong LILutao JIANGYong SUN

【Author】 Miao YU;Shangcong HAN;Jialing DAI;Jiao LIU;Chen WEI;Yitong LI;Lutao JIANG;Yong SUN;School of Pharmacy,Qingdao University;

【机构】 School of Pharmacy,Qingdao University

【摘要】 [Objectives] To prepare Ibuprofen-β-CD for thermosensitive in situ gel administration to achieve a slow drug release. [Methods]By saturation solution process,the best inclusion technology was screened out with orthogonal design. [Results]The prescription of in situ gel contained ibuprofen-β-CD complex,poloxamer P407,P188,and HPMCK4M( w/v 10%,18%,3%,and 0. 5%). The gelation temperature of ibuprofen gel was 34. 6 ± 0. 3℃. The viscosity of ibuprofen gel increased significantly above 35℃ and showed semi-solid attribute. [Conclusions] The release of ibuprofen from in situ gel was slow and stable in 96 h,demonstrated a proximate zero order release between 24 h and 96 h.

【基金】 Supported by Shandong Science and Technology Development Project in 2014(2014GSF118168);National Natural Science Foundation in 2016(81673360)
【所属期刊栏目】 Pharmacological and Toxicological Analyses (2017年02期)
  • 【分类号】R943
  • 【下载频次】36
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