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Effect of Panax Notoginseng Saponins in the Treatment of Traumatic Spinal-cord Injury in Rats: A Meta-Analysis

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【作者】 Xiang ZHANGYing CHENLiqun REN

【Author】 Xiang ZHANG;Ying CHEN;Liqun REN;Chengde Medical College;

【机构】 Chengde Medical College

【摘要】 [Objectives] To systemically review the efficacy and safety of Panax Notoginseng Saponins( PNS) in the treatment of traumatic spinal-cord injury( TSCI) in rat models. [Methods] Randomized controlled trials( RCT) about the effects of PNS for TSCI in rats were searched in Pub Med,EMbase,The Cochrane Library,CBM,CNKI,Wan Fang Data from inception to November 2016. Two reviewers independently screened literature according to the inclusion and exclusion criteria,extracted data,and assessed the risk of bias of included studies.Then Meta-analysis was performed using Rev Man 5. 3 software. [Results] A total of 6 RCTs involving 264 rats were included. The results of Meta-analysis showed that: compared with the control group,the Basso,Beattie and Bresnahan( BBB) scores in the PNS group were superior in 7 days( SMD = 1. 81,95% CI( 1. 18,2. 43),P < 0. 00001),14 days( SMD = 1. 92,95% CI( 1. 51,2. 33),P < 0. 00001),21 days( SMD =2. 33,95% CI( 0. 98,3. 68),P <0. 0007) and 28 days( SMD =2. 72,95% CI( 1. 78,3. 67),P <0. 00001) after surgery. The results of Meta-analysis showed that: compared with the control group,ramp test in the PNS group were superior in 7 days [SMD = 1. 55,95% CI( 0. 78,2. 31),P <0. 0001]and 14 days[SMD =1. 83,95% CI( 1. 46,2. 20),P < 0. 00001]. [Conclusions] Current evidence indicates that PNS can promote the recovery of motor function in the rats with TSCI. Due to limited quality of the included studies,the above conclusion should be verified by conducting more large-scale,high quality RCTs.

【所属期刊栏目】 Clinical Application (2017年06期)
  • 【DOI】10.19600/j.cnki.issn2152-3924.2017.06.015
  • 【分类号】R285.5
  • 【下载频次】28
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