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Optimization of Proportion and Formulation Process of Jinweng Granule by D-Optimal Mixture Design

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【作者】 Xin YUELi LIUYongfeng HAOJuan LIUDengfang CHENGQingchang YANGXianchao YANGXuehong HU

【Author】 Xin YUE;Li LIU;Yongfeng HAO;Juan LIU;Dengfang CHENG;Qingchang YANG;Xianchao YANG;Xuehong HU;Traditional Chinese Medicine Innovation Research Laboratory,College of Animal Sciences,Southwest University;Veterinary Science Engineering Center of Chongqing;Veterinary Drug Research Institute,Sichuan Baer Agriculture Group Co.,Ltd.;

【机构】 Traditional Chinese Medicine Innovation Research Laboratory,College of Animal Sciences,Southwest UniversityVeterinary Science Engineering Center of ChongqingVeterinary Drug Research Institute,Sichuan Baer Agriculture Group Co.,Ltd.

【摘要】 [Objectives] To study the optimal proportion and formulation process of Jinweng granule,the physicochemical properties of the optimal preparing process was observed. [Methods] Adopting the D-optimal mixture design method,selecting the mixing ratio of starch,dextrin,fumei powder and lactose as tested factors,and selecting the most significant factor between hygroscopicity,formability,solubility as the evaluation index,the optimal proportion of filler was examined by system experiments. Granularity,solubility,the angle of repose,and critical relative humidity( CRH) were used to evaluate the optimal proportion and formulation process of Jinweng granule. [Results]The optimal prescription of Jinweng granule is extract∶ starch∶ dextrin∶ lactose∶ fumei powder( 1∶ 0. 5∶ 0. 05∶ 0. 3∶ 0. 15),and the binder was consisted of 1% sodium carboxymethylcellulose( CMC) slurry and 3% starch syrup. The CRH of the optimum formulation process of granule is 72%,and the fluidity,solubility and granularity were qualified. [Conclusions] The process model established by D-optimum mixture design has good predictability,and the granule prepared by the optimal proportion has good repeatability,and the granule proportion and formulation process is stable and reliable.

【基金】 Supported by Public Welfare and Industry Special Fund Project of the Ministry of Agriculture(201303040-05);Natural Science Foundation Project of CQCSTC(2013FYF110600)
【所属期刊栏目】 Processing of Traditional Chinese Medicine and Quality Control (2018年01期)
  • 【DOI】10.19600/j.cnki.issn2152-3924.2018.01.008
  • 【分类号】TQ461
  • 【下载频次】19
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