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Protective Effect of Shenfu Injection on Rats with Chronic Heart Failure Induced by Doxorubicin

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【作者】 Qingli LIGuirong ZENGZhichao TANXiaoqing WANGHongliang ZENG

【Author】 Qingli LI;Guirong ZENG;Zhichao TAN;Xiaoqing WANG;Hongliang ZENG;Hunan Key Laboratory of Pharmacodynamics and Safety Evaluation of New Drugs;Zhejiang Ai Fu Quan Pharmaceutical Co.,Ltd.;Hunan Fang Sheng Pharmaceutical Co.,Ltd. Postdoctoral Work Station;

【通讯作者】 Hongliang ZENG;

【机构】 Hunan Key Laboratory of Pharmacodynamics and Safety Evaluation of New DrugsZhejiang Ai Fu Quan Pharmaceutical Co.,Ltd.Hunan Fang Sheng Pharmaceutical Co.,Ltd. Postdoctoral Work Station

【摘要】 [Objectives] To determine the protective effect of Shenfu injection( SFI) on chronic heart failure( CHF) in rats induced by doxorubicin. [Methods] CHF was induced by doxorubicin via intraperitoneal injection in rats. The cardiac function parameters,the heart index,the serum brain natriuretic peptide( BNP) level and cardiac histopathology were measured 4 weeks after Shenfu injection treatment. [Results]Shenfu injection remarkably improved the heart index and cardiac histopathology,increased the heart rate( HR),left ventricular systolic pressure( LVSP),maximum rising rate of left ventricular pressure( + dp/dtmax) and dropping rate of left ventricular pressure(-dp/dtmax),reduced the left ventricular end-diastolic pressure( LVEDP) and serum BNP level of rats with CHF induced by doxorubicin. [Conclusions]Shenfu injection exerts protective effect on CHF induced by doxorubicin.

【所属期刊栏目】 Clinical Application (2018年04期)
  • 【DOI】10.19600/j.cnki.issn2152-3924.2018.04.031
  • 【分类号】R285.5
  • 【下载频次】11
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