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Study on Alkaloids in Fructus Hordei Germinatus

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【作者】 Jianheng GUOGuozhu LIQingyan MENGJizhong ZHANG

【Author】 Jianheng GUO;Guozhu LI;Qingyan MENG;Jizhong ZHANG;School of Pharmacy,Southwest Minzu University;Alar First Division of Institute for Food and Drug Control;Key Laboratory of Resource Protection and Utilization of Tarim Basin,Xinjiang Production & Construction;Ethnic Medicine Institute,Southwest Minzu University;

【通讯作者】 Qingyan MENG;

【机构】 School of Pharmacy,Southwest Minzu UniversityAlar First Division of Institute for Food and Drug ControlKey Laboratory of Resource Protection and Utilization of Tarim Basin,Xinjiang Production & ConstructionEthnic Medicine Institute,Southwest Minzu University

【摘要】 [Objectives]To isolate and analyze alkaloids in Fructus Hordei Germinatus.[Methods]The alkaloids in the Fructus Hordei Germinatus were extracted by ultrasonic technology,and analyzed by the ultra-performance liquid chromatography tandem mass spectrometry(UPLC-MS/MS) technique.[Results] According to the mass spectrometry information,compared with the literature reports,the possible structures of seven alkaloids in the Fructus Hordei Germinatus could be inferred.Compounds 1,2 and 3 were organic amine alkaloids,respectively tyramine and N-methyltyramine,hordenine,compounds 4,5,6 and 7 were indole alkaloids,respectively,tryptamine,gramine,harmine,and bufotenidine.The alkaloids in the Fructus Hordei Germinatus were separated by preparative high performance liquid chromatography(p HPLC) technique,a compound was obtained and identified by UPLC-MS/MS and nuclear magnetic resonance(NMR) technique as hordenine.[Conclusions]This experiment is expected to lay a foundation for the development of alkaloids in the Fructus Hordei Germinatus.

【基金】 Supported by Innovating Research Program of Postgraduates of Southwest Minzu University in 2017(CX2017SZ086)
【所属期刊栏目】 Chemical Composition of Natural Medicine (2018年06期)
  • 【DOI】10.19600/j.cnki.issn2152-3924.2018.06.005
  • 【分类号】R284.1
  • 【被引频次】2
  • 【下载频次】7
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