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Screening of Anti-inflammatory and Analgesic Parts of Ardisia gigantifolia stapf.and Its Toxicological Safety Study

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【作者】 Weibo DAIHongnian LIPengpeng DONGQuanxi MEI

【Author】 Weibo DAI;Hongnian LI;Pengpeng DONG;Quanxi MEI;Zhongshan Hospital,Guangzhou University of Traditional Chinese Medicine;

【通讯作者】 Weibo DAI;

【机构】 Zhongshan Hospital,Guangzhou University of Traditional Chinese Medicine

【摘要】 [Objectives] To screen out the anti-inflammatory and analgesic parts of Ardisia gigantifolia stapf.and to explore the toxicological safety of each part.[Methods]The carrageenan-induced toe swelling experiment of mice,acetic acid-induced peritoneal capillary permeability experiment,pain writhing test,and mouse maximum tolerated dose experiment were carried out.Taking mouse toe swelling,capillary permeability,pain writhing reaction times,and animal death number as indicators,anti-inflammatory and analgesic effects were screened and toxicological safety was evaluated for petroleum ether,ethyl acetate,n-butanol and water parts of A.gigantifolia.[Results] The petroleum ether part of A.gigantifolia can significantly reduce the degree of carrageenan-induced toe swelling of(P < 0.05),significantly inhibit the glacial acetic acid induced capillary permeability of mice(P < 0.05) and the times of pain writhing of mice(P < 0.01),no death was observed in each group after 150-fold of clinical equivalent dose administration,and no abnormality was observed in body weight and tissues of mice.[Conclusions]The petroleum ether part of A.gigantifolia is active part of anti-inflammatory and analgesic effect,and each part is low in toxicological safety.

【基金】 Supported by the Project of Traditional Chinese Medicine Bureau of Guangdong Province(20171282)
【所属期刊栏目】 Pharmacological and Toxicological Analyses (2018年06期)
  • 【DOI】10.19600/j.cnki.issn2152-3924.2018.06.008
  • 【分类号】R285
  • 【下载频次】17
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