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Effects of Quercetin on Blood Pressure in Animals:A Systematic Review and Meta-analysis

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【作者】 Yi ZHANGBing WEIShiying TANG

【Author】 Yi ZHANG;Bing WEI;Shiying TANG;Institute of Chinese Materia Medica/Hebei Key Laboratory of Research and Exploitation of Traditional Chinese Medicine,Chengde Medical College;Chengde Medical College;

【通讯作者】 Shiying TANG;

【机构】 Institute of Chinese Materia Medica/Hebei Key Laboratory of Research and Exploitation of Traditional Chinese Medicine,Chengde Medical CollegeChengde Medical College

【摘要】 [Objectives] To make a systematic evaluation of the efficacy and safety of quercetin on animal blood pressure.[Methods] The CNKI,Wan Fang,VIP,CBM,Pubmed,and Cochrane Library databases were searched for the literature about the effects of quercetin on blood pressure in the period from the creation of databases to April 2018.Two researchers separately screened literature and extracted data.Meta-analysis was carried out with the aid of Rev Men 5.3 software.[Results]A total of 10 articles were included,involving 288 animals.All animals were rodents.Meta-analysis results showed that there was a statistically significant difference in Systolic Blood Pressure(SBP) between the quercetin group and the control group.MD =-21.43,95% CI(-28.99,-13.86),P < 0.000 01;subgroup analysis,hypertensive animal group,MD =-29.52,95% CI(-36.05,-22.98),P < 0.000 01;the ability of quercetin group in lowering blood pressure was better than that of the control group,and the difference was statistically significant;in the normal blood pressure group,MD =-0.49,95% CI(-3.74,2.77),P = 0.77,the quercetin group was basically the same as the control group,the difference was not statistically significant.[Conclusions] Compared with the blank control group,quercetin can effectively reduce the blood pressure of hypertensive animals,but it has little effect on the blood pressure of normal animals.Besides,further study is needed on the safety of quercetin.

【所属期刊栏目】 Pharmacological and Toxicological Analyses (2018年06期)
  • 【DOI】10.19600/j.cnki.issn2152-3924.2018.06.009
  • 【分类号】R285.5
  • 【被引频次】1
  • 【下载频次】29
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