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Preparation and in vitro Release of Donepezil Hydrochloride Microspheres

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【作者】 Yingzhou WANGHao QIDongze ZHANGZixuan ZHAOChunyan ZHANG

【Author】 Yingzhou WANG;Hao QI;Dongze ZHANG;Zixuan ZHAO;Chunyan ZHANG;School of Pharmacy,Jining Medicinal College;

【通讯作者】 Chunyan ZHANG;

【机构】 School of Pharmacy,Jining Medicinal College

【摘要】 [Objectives]To prepare donepezil hydrochloride microspheres and evaluate their quality.[Methods]The donepezil hydrochloride microspheres were prepared by emulsification-solvent evaporation method.The morphology was observed by scanning electron microscopy and the particle size distribution was determined by Laser Diffraction Method.The encapsulation efficiency,drug loading capacity,and in vitro release were determined by HPLC.[Results]The prepared donepezil hydrochloride microspheres were spherical with the average particle diameter of 15.927 μm.The drug loading capacity was 35.62%.The encapsulation efficiency was 90.32%.The drug release in vitro lasted for14 d.The release curve accorded with the first-order kinetic equation.[Conclusions]The prepared donepezil hydrochloride microspheres performed good sustained release effect in vitro,and it was expected to be used for research on Parkinson’s disease.

【基金】 Supported by National Innovative Training Program for College Students(201610443020)
【所属期刊栏目】 Processing of Traditional Chinese Medicine and Quality Control (2018年06期)
  • 【DOI】10.19600/j.cnki.issn2152-3924.2018.06.017
  • 【分类号】R943
  • 【下载频次】10
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