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Comparative Study on Effects of Rheum officinale and Wine Prepared Rheum palmatum Dachengqi Decoction on Laxative Effect of Mice

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【作者】 Jiangcun WEIYong CHENZhen XIEDongmei HUANGZijun CHENJinzhou LIZuliang QUEQian HAN

【Author】 Jiangcun WEI;Yong CHEN;Zhen XIE;Dongmei HUANG;Zijun CHEN;Jinzhou LI;Zuliang QUE;Qian HAN;Guangxi International Zhuang Medical Hospital;Guangxi University of Chinese Medicine;

【通讯作者】 Yong CHEN;

【机构】 Guangxi International Zhuang Medical HospitalGuangxi University of Chinese Medicine

【摘要】 [Objectives] To study the differences in the effects of Rheum officinale and wine prepared Rheum palmatum Dachengqi Decoction(DCQ) on laxative effect of mice.[Methods]First,72 mice were randomly divided into positive control group,blank control group,6 and10 g/kg dose R.officinale DCQ groups,6 and 10 g/kg dose wine prepared R.palmatum DCQ groups.After administration at the dose of20 m L/kg,metabolic cage method and carbon powder propulsion were used to conduct Na+-K+-ATPasc activity experiment,and the comparison was made for the differences in the normal laxative effect of R.officinale and wine prepared R.palmatum on DCQ,the carbon powder propulsion rate,and Na+-K+-ATPasc activit.[Results]There are differences in the laxative effect of R.officinale and wine prepared R.palmatum on DCQ,but their differences in changes are,to some extent,connected with R.officinale and wine prepared R.palmatum.From comparison of R.officinale DCQ group,wine prepared R.palmatum DCQ group,blank control group,and positive control group,it is found that there are differences in the normal laxative effect of normal mice,carbon powder propulsion,and inhibition of Na+-K+-ATPase activity.In addition,the comparison of drug administration groups indicates that the differences in the effects of R.officinale DCQ group are most significant,and there are significant differences in the 6 and 10 g/kg groups.[Conclusions]There are certain differences in the influence of R.officinale and wine prepared R.palmatum Dachengqi Decoction on normal laxative effect of mice,which may be connected with the fact that changes in main chemical components of king drugs R.officinale and wine prepared R.palmatum lead to changes in the dissolution amount of anthraquinones in the compound Dachengqi Decoction.

【基金】 Supported by Project of National Natural Science Foundation(81360524&81660701);Natural Science Foundation Project of Guangxi(2016 GXNSFAA380148&2014GXNSFAA118208);Program of Key Laboratory for Purification and Quality Analysis of TCM Extraction in Guangxi Universities(Gui Jiao Ke Yan[2014]No.6);Program of Scientific Research Third-level Laboratory “Chinese(Zhuang) Medicine Chemical and Quality Analysis Laboratory” of State Administration of Traditional Chinese Medicine(Guo Zhong Yi Yao Fa 2009[No.21])
【所属期刊栏目】 Clinical Application (2018年06期)
  • 【DOI】10.19600/j.cnki.issn2152-3924.2018.06.023
  • 【分类号】R285.5
  • 【被引频次】1
  • 【下载频次】21
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