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Hemostatic and Anti-inflammatory Activities and High Performance Liquid Chromatography Analysis of Rotala rotundifolia and Its Preparations

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【作者】 Jiaxing CHENXingguo ZHANGQun LUXiao LUOLuncai LUO

【Author】 Jiaxing CHEN;Xingguo ZHANG;Qun LU;Xiao LUO;Luncai LUO;School of Life Science and Engineering,Southwest Jiaotong University;School of Material Science and Engineering,Southwest Jiaotong University;Second People’s Hospital of Liangshan Yi Autonomous Prefecture;

【通讯作者】 Xingguo ZHANG;

【机构】 School of Life Science and Engineering,Southwest Jiaotong UniversitySchool of Material Science and Engineering,Southwest Jiaotong UniversitySecond People’s Hospital of Liangshan Yi Autonomous Prefecture

【摘要】 [Objectives] To evaluate the hemostatic and anti-inflammatory activities of water extract and ethanol extract of Rotala rotundifolia and Shuijia Zhixue capsule. [Methods]The hemostatic activity of the extracts was evaluated by the changes of the bleeding time( BT),coagulation time( CT) and coagulation parameters including prothrombin time( PT),activated partial thromboplastin time( APTT) and thrombin time( TT) in mice or rats. The anti-inflammatory activity of the extracts was evaluated by carrageenan-induced foot edema,arachidonic acidinduced ear edema and xylene-induced ear edema models in rats. The content of gallic acid in ethanol extracts of R. rotundifolia and Shuijia Zhixue capsule was studied by HPLC to explore the correlation between gallic acid and anti-inflammatory activity. [Results]In hemostasis experiment,the ethanol extracts of R. rotundifolia and Shuijia Zhixue capsules showed significant shortening effects on BT,CT,PT and TT( P <0. 01-0. 05). The water extracts of R. rotundifolia and Shuijia Zhixue capsules had significant shortening effects on CT,PT and TT( P <0. 05),while the water extracts of R. rotundifolia had no hemostasis effect. In anti-inflammatory experiment in vivo,the two ethanol extracts showed significant shortening effects on CT,PT and TT and in the induction test of carrageenan,arachidonic acid and xylene,the inhibitory effects were significant( P < 0. 01-0. 05). The water extract from Shuijia Zhixue capsules had significant inhibitory effects on carrageenan-induced foot edema in rats( P < 0. 05),but the anti-inflammatory effects of water extract from R. rotundifolia were not significant. The content of gallic acid in R. rotundifolia and Shuijia Zhixue capsules were( 0. 318 62 ± 0. 009 8) and( 6. 295 2 ± 0. 162 6) mg/g,respectively.Among them,the content of gallic acid in Shuijia Zhixue capsule was significantly correlated with the anti-inflammatory activity of carrageenaninduced foot edema model. [Conclusions] Ethanol extract of R. rotundifolia and Shuijia Zhixue capsules has strong hemostatic and anti-inflammatory activities,and can be used in the treatment of traditional diseases such as bleeding and inflammation.

【基金】 Supported by the Project of Sichuan Provincial Science and Technology Department(2017SZYZF0012);the Project of Science and Technology Bureau of Sichuan Liangshan Yi Autonomous Prefecture(15yyjs0002)
【所属期刊栏目】 Chemical Composition of Natural Medicine (2019年03期)
  • 【DOI】10.19600/j.cnki.issn2152-3924.2019.03.006
  • 【分类号】R285.5
  • 【下载频次】6
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