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Effects of Tiaomaiyin and Its Disassembled Prescription on Expression of L-type Calcium Channel β2 Subunit in Rat Model of Tachyarrhythmia

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【作者】 Jingze SUYao HANZhizhen WEIWen SUNTianyu QIN

【Author】 Jingze SU;Yao HAN;Zhizhen WEI;Wen SUN;Tianyu QIN;Beijing Xuanwu Traditional Chinese Medicine Hospital;Beijing Traditional Chinese Medicine Hospital Capital Medical University;School of Traditional Chinese Medicine,Beijing University of Chinese Medicine;Dongfang Hospital of Beijing University of Chinese Medicine;

【通讯作者】 Jingze SU;

【机构】 Beijing Xuanwu Traditional Chinese Medicine HospitalBeijing Traditional Chinese Medicine Hospital Capital Medical UniversitySchool of Traditional Chinese Medicine,Beijing University of Chinese MedicineDongfang Hospital of Beijing University of Chinese Medicine

【摘要】 [Objectives] To study the effects of Tiaomaiyin and its disassembled prescription on expression of L-type calcium channel β2 subunit in rat model of tachyarrhythmia. [Methods] Sixty Wistar rats were randomly divided into model group,Tiaomaiyin prescription group( whole prescription group),main efficacy group of removing heat to cool blood( blood cooling group),and auxiliary drug efficacy group of benefiting qi and nourishing heart( qi benefiting group),auxiliary efficacy group of promoting flow of qi and blood circulation( qi flow promoting group),and amiodarone group( western medicine group). Aconitine was given 7 d after the intragastric administration of the corresponding drugs,and the time of occurrence of arrhythmia in each group was observed. The left ventricular myocardium was subjected to reverse transcription-polymerase chain reaction and Western blotting. [Results] The ventricular premature beats( VPB) time in the whole prescription group and western medicine group was significantly longer than that in the model group. Ventricular tachycardia( VT),ventricular fibrillation( VF),and cardiac arrest( CA) were longer in the whole prescription group,blood cooling group,and western medicine group. The mRNA and protein expression of L-type calcium channel β2 subunit in the whole prescription group,blood cooling group and western medicine group were significantly decreased. [Conclusions] Tiaomaiyin whole prescription group and blood cooling group can reduce the occurrence time of tachyarrhythmia and reduce the expression of LTCC β2 in myocardium.

【基金】 Supported by the Project of Beijing Municipal Natural Science Foundation(7173261)
【所属期刊栏目】 Pharmacological and Toxicological Analyses (2019年03期)
  • 【DOI】10.19600/j.cnki.issn2152-3924.2019.03.008
  • 【分类号】R285.5;R-332
  • 【下载频次】7
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