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Effects of Paeonol on CRP and NF-κB p65 in Rats with Atherosclerosis

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【作者】 Yanfang FANYanan ZHAOKaihang SHIZhuoya JIAXiaohui ZHOU

【Author】 Yanfang FAN;Yanan ZHAO;Kaihang SHI;Zhuoya JIA;Xiaohui ZHOU;Chengde Medical University;

【通讯作者】 Xiaohui ZHOU;

【机构】 Chengde Medical University

【摘要】 [Objectives] The protective mechanism of paeonol on atherosclerotic vessels was investigated by detecting CRP content in the serum and expression of NF-κB p65 in the aorta of atherosclerotic rats. [Methods] An animal model of AS rats was prepared by high-fat diet combined with intraperitoneal injection of VD3. The rats were randomly divided into the normal group,model group,high-dose paeonol group( 120 mg/kg),medium-dose paeonol group( 60 mg/kg),low-dose paeonol group( 30 mg/kg),and simvastatin group( 10 mg/kg) as the positive control group,and drug intervention was continued for 16 weeks. CRP content in the serum was detected by ELISA method,and the expression level of NF-κB p65 was detected by RT-PCR and Western-blot method. [Results]Compared with the normal group,CRP content in the serum and the expression of NF-κB p65 mRNA and protein in the aorta of rats in the model group significantly increased. Compared with the model group,CRP content in the serum dropped obviously,and the expression of NF-κB p65 mRNA and protein in the aorta of rats significantly reduced in the administration groups. Moreover,the improvement of each indicator in the high-dose paeonol group was obviously better than that of the medium-dose and low-dose groups. [Conclusions] Paeonol may protect atherosclerotic vessels by reducing serum CRP content,inhibiting the expression of NF-κB p65 and reducing inflammation.

【基金】 Supported by Foundation for Young Scholars of Hebei Education Department(Q2012015)
【所属期刊栏目】 Pharmacological and Toxicological Analyses (2019年03期)
  • 【DOI】10.19600/j.cnki.issn2152-3924.2019.03.009
  • 【分类号】R285.5
  • 【下载频次】13
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