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Immunoregulatory Effects of Sanguis Draconis Flavones on Mouse Spleen Lymphocytes

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【作者】 Dewu JIADongrui XUDeyun JIARui LI

【Author】 Dewu JIA;Dongrui XU;Deyun JIA;Rui LI;Department of Pharmacy,First Affiliated Hospital of Anhui Medical University;School of International Education,Anhui Xinhua University;Anhui Academy of Medical Sciences;

【通讯作者】 Rui LI;

【机构】 Department of Pharmacy,First Affiliated Hospital of Anhui Medical UniversitySchool of International Education,Anhui Xinhua UniversityAnhui Academy of Medical Sciences

【摘要】 [Objectives] This study aimed to study the effects of Sanguis Draconis flavones( SDF) on the immune regulation of mouse spleen lymphocytes. [Methods]A total of 60 BALB/c male mice were evenly and randomly divided into normal control group,model group,positive group,and high,middle and low-dose SDF groups. The mice in the model group were injected intraperitoneally with cyclophosphamide to establish mouse immunosuppressive model. The mice in the other groups were intragastrically administered at the respective doses,and the body weight was weighed once a week during the administration period. After 30 d of administration,the thymus and spleen indexes,the spleen lymphocyte proliferation ability,the NK cell activity,and the IL-2,IL-4 and INF-γ contents in the culture supernatant were measured. [Results]SDF could significantly increase the thymus and spleen indexes and improve the spleen lymphocyte proliferation ability and NK cell activity of the mice,as well as increasing the IL-2 and INF-γ contents and reducing the IL-4 content in spleen lymphocyte suspension culture. [Conclusions] SDF have good immunoregulatory effect.

【基金】 Supported by Foundation of Anhui Academy of Medical Sciences(YKY2018006)
【所属期刊栏目】 Pharmacological and Toxicological Analyses (2019年03期)
  • 【DOI】10.19600/j.cnki.issn2152-3924.2019.03.012
  • 【分类号】R285.5
  • 【下载频次】10
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