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Effects of Xuebijing Combined with Ulinastatin on Coagulation Function of Sepsis Patients

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【作者】 Yongping ZHANGXuhong TANQin LIHanlin TANGZaiqun WANGLi XU

【Author】 Yongping ZHANG;Xuhong TAN;Qin LI;Hanlin TANG;Zaiqun WANG;Li XU;The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine;

【通讯作者】 Yongping ZHANG;

【机构】 The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine

【摘要】 [Objectives] To study the effects of Xuebijing combined with ulinastatin on coagulation function of sepsis patients. [Methods]Fifty six patients conforming to the diagnosis criteria for sepsis and receiving the treatment from May 2015 to January 2019 were selected. They were randomly divided into treatment group and control group according to the order of treatment. The two groups were treated according to the International Guidelines for Management of Severe Sepsis and Septic Shock( 2012),in which ulinastatin and Xuebijing were added to the treatment group. Before the treatment and on the seventh day after the treatment,both groups of patients were measured for the activated partial thromboplastin time( APTT),fibrinogen( Fi B),platelet( PLT),and prothrombin time( PT) were measured; the treatment status of the both groups was continuously observed for 7 d,and the mechanical ventilation time,ICU hospitalization time,and 30-day survival rate were recorded. [Results] Both FIB and PLT of the treatment group were significantly increased,and both APTT and PT were significantly shortened.Compared with the control group,the difference was statistically significant( P < 0. 05). The mechanical ventilation time and ICU hospitalization time of the treatment group were significantly shorter than that of the control group,and the 30-day survival rate of the treatment group was significantly higher than that of the control group,and the difference was statistically significant( P < 0. 05). [Conclusions]Xuebijing combined with ulinastatin can improve coagulation disorders of sepsis patients.

【所属期刊栏目】 Clinical Application (2019年03期)
  • 【DOI】10.19600/j.cnki.issn2152-3924.2019.03.022
  • 【分类号】R459.7
  • 【下载频次】8
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