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Efficacy of Yinzhihuang Granules and Entecavir on Hepatitis B-induced Cirrhosis

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【作者】 Fen TANGGuifang TANGRuiling CHENZhenyi LIURiming WEI

【Author】 Fen TANG;Guifang TANG;Ruiling CHEN;Zhenyi LIU;Riming WEI;Department of Infectious Diseases, Nanxishan Hospital of Guangxi Zhuang Autonomous Region;Guilin Medical University;

【通讯作者】 Riming WEI;

【机构】 Department of Infectious Diseases, Nanxishan Hospital of Guangxi Zhuang Autonomous RegionGuilin Medical University

【摘要】 [Objectives] This study aimed to observe the efficacy and safety of Yinzhihuang granules and entecavir in the treatment of hepatitis B-induced cirrhosis. [Methods] Total 80 patients with decompensated hepatitis B-induced cirrhosis were evenly and randomly divided into two groups, treatment group and control group. The patients in the treatment group were given orally with 0.25 mg entecavir and 5 000 mg Yinzhihuang granules once a day, and those in the control group were given orally with 0.5 mg entecavir once a day. The levels of aspartate aminotransferase(AST), alanine aminotransferase(ALT), hyaluronic acid(HA) and HBV DNA, the Child-Pugh score, and the positive situation of HBeAg in different groups were observed before treatment and 12, 24, 48 and 96 weeks after the treatment, respectively. [Results] The serum ALT, AST, HA and HBV DNA levels, the HBeAg positive rate, and the Child-Pugh score in the treatment and control groups were significantly improved after the treatment(P<0.05). The improvement of the above indicators in the treatment group at week 96 was significantly better than that in the control group(P<0.05). [Conclusions] The combination of Yinzhihuang granules and entecavir is superior to entecavir in the treatment of decompensated hepatitis B-induced cirrhosis.

【基金】 Supported by Self-raised Fund of Health and Family Planning Commission of Guangxi Zhuang Autonomous Region(Z2015224);National Natural Science Foundation of Guangxi(2017GXNSFAA198326)
【所属期刊栏目】 Clinical Application (2019年05期)
  • 【DOI】10.19600/j.cnki.issn2152-3924.2019.05.020
  • 【分类号】R512.62;R575.2
  • 【下载频次】6
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