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Stability of Sanguinarine and Chelerythrine in Macleaya cordata (Willd.) R. Br.

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【作者】 Chunmei LIXu CHENWenlan LIBingmei LIULi WANGYubin JI

【Author】 Chunmei LI;Xu CHEN;Wenlan LI;Bingmei LIU;Li WANG;Yubin JI;School of Pharmacy, Harbin University of Commerce;Engineering Research Center of Natural Anti-tumor Drugs, Ministry of Education;Post-doctoral Research Center of Drugs Research Institute;Nangang Branch Hospital, Heilongjiang Provincial Hospital;

【通讯作者】 Yubin JI;

【机构】 School of Pharmacy, Harbin University of CommerceEngineering Research Center of Natural Anti-tumor Drugs, Ministry of EducationPost-doctoral Research Center of Drugs Research InstituteNangang Branch Hospital, Heilongjiang Provincial Hospital

【摘要】 [Objectives] To explore the stability of sanguinarine and chelerythrine in Macleaya cordata(Willd.) R. Br. [Methods] The solubility and stability of sanguinarine and chelerythrine in seven solvents were measured by HPLC. Besides, the effects of water quality, light source, oxidant, temperature, and pH on stability were investigated. [Results] The solubility and stability of sanguinarine and chelerythrine in methanol and ethanol are good; the stability of sanguinarine and chelerythrine in distilled water and rainwater is not affected by light and is very stable, but they are unstable in tap water whether they are protected from light or not; oxidants have a great influence on the stability of sanguinarine and chelerythrine; sanguinarine and chelerythrine are stable at room temperature lower than 54 ℃; sanguinarine is stable in pH 2.5-7.0, while chelerythrine is stable in pH 2.5-8.0. [Conclusions] The good stability of sanguinarine and chelerythrine under specific conditions shows that they have broad development prospects and value.

【基金】 Supported by Post-doctoral Foundation Project of Heilongjiang Province(LBHZ16094);Special Research Fund Project for Scientific and Technological Innovation Talents in Harbin City(2017RAQXJ115);Doctoral Starting up Project of Harbin University of Commerce(2019DS114)
【所属期刊栏目】 Chemical Composition of Natural Medicine (2019年06期)
  • 【DOI】10.19600/j.cnki.issn2152-3924.2019.06.006
  • 【分类号】R284
  • 【下载频次】2
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