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Effects of Alcohol Extract of Giantleaf Ardisia Rhizome on Levels of Inflammatory Factors in Serum of Rats with Adjuvant Arthritis

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【作者】 Weibo DAIFengrong WUPengpeng DONGCongyan ZENGQuanxi MEI

【Author】 Weibo DAI;Fengrong WU;Pengpeng DONG;Congyan ZENG;Quanxi MEI;Affiliated Zhongshan Hospital of Guangzhou University of Chinese Medicine;

【通讯作者】 Weibo DAI;

【机构】 Affiliated Zhongshan Hospital of Guangzhou University of Chinese Medicine

【摘要】 [Objectives] The purpose of this study was to investigate the effects of ethanol extract of Giantleaf Ardisia Rhizome on the serum levels of interleukin 6(IL-6), tumor necrosis factor α(TNF-α) and interleukin-1β(IL-1β) in adjuvant arthritis(AA) rats induced by Freund’s complete adjuvant(CFA), so as to investigate its role in the treatment of rheumatoid arthritis. [Methods] Rat models of AA were induced by CFA, and they were given with different doses of ethanol extract of Giantleaf Ardisia Rhizome, followed by scoring of systemic and joint inflammation and swelling degree and determination of serum IL-6, TNF-α and IL-1β levels. [Results] Compared with the model group, the ethanol extract of Giantleaf Ardisia Rhizome significantly reduced the scores of systemic and joint inflammation and swelling degree and the serum levels of IL-6, TNF-α and IL-1β in AA rats(P<0.05, P<0.01). [Conclusions] The ethanol extract of Giantleaf Ardisia Rhizome can suppress the development of AA in rats and the mechanism may be related to the down-regulation of the expression of serum inflammatory factors(IL-6, TNF-α, IL-1β).

【基金】 Supported by Zhongshan Science and Technology Plan Project(2019B1014)
【所属期刊栏目】 Pharmacological and Toxicological Analyses (2019年06期)
  • 【DOI】10.19600/j.cnki.issn2152-3924.2019.06.016
  • 【分类号】R285.5
  • 【下载频次】3
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