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Establishment of Variable-wavelength Fingerprint for Yixinshu Tablets

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【作者】 Yuanchun QIYanchun ZHENGLi CHUChunmin WANG

【Author】 Yuanchun QI;Yanchun ZHENG;Li CHU;Chunmin WANG;Chengde Medical College;Jingfukang Pharmaceutical Group Co., Ltd.;New Excipients of Traditional Chinese Medicine Engineering Research Center of Hebei Province;

【通讯作者】 Chunmin WANG;

【机构】 Chengde Medical CollegeJingfukang Pharmaceutical Group Co., Ltd.New Excipients of Traditional Chinese Medicine Engineering Research Center of Hebei Province

【摘要】 [Objectives] The purpose of this study was to establish the HPLC fingerprint of Yixinshu tablets, in order to provide a basis for quality control of Yixinshu tablets. [Methods] The chromatographic conditions were as follows: column, Agilent 5 TC-C18(2)(250 mm×4.6 mm, 5 μm); mobile phase, acetonitrile-0.02% phosphoric acid solution(gradient elution); column temperature, 25 ℃; detection wavelength, 280 nm(0-62 min) and 260 nm(62-125 min). Using salvianolic acid B as the reference, the fingerprints of nine batches of Yixinshu tablets were determined. The similarity between the fingerprints was evaluated according to the Similarity Evaluation System for Chromatographic Fingerprint of TCM(Version 2012). [Results] A total of 25 common peaks were calibrated, 10 of which were identified. The similarity between the fingerprints of the nine batches of Yixinshu tablets and the reference fingerprint was all greater than 95%, indicating good similarity. [Conclusions] The established HPLC fingerprint can be applied to the quality control of Yixinshu tablets.

【所属期刊栏目】 Biotechnology (2019年06期)
  • 【DOI】10.19600/j.cnki.issn2152-3924.2019.06.022
  • 【分类号】R286.0
  • 【下载频次】7
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