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Study on Quality Standards of Children Antipyretic Lotion

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【作者】 Suhong QINJiahuan WEIGuangyuan XIEZhenyuan WEILilong YANGYuqing ZHOUMin HUANG

【Author】 Suhong QIN;Jiahuan WEI;Guangyuan XIE;Zhenyuan WEI;Lilong YANG;Yuqing ZHOU;Min HUANG;The First Affiliated Hospital of Guangxi University of Chinese Medicine;

【通讯作者】 Min HUANG;

【机构】 The First Affiliated Hospital of Guangxi University of Chinese Medicine

【摘要】 [Objectives] To establish suitable quality standards of children antipyretic lotion. [Methods] Qualitative identification was performed for Paederia scandens and Artemisia carvifolia in Children Antipyretic Lotion by thin-layer chromatography(TLC), and the content of paederosidic acid in children antipyretic lotion was determined by high performance liquid chromatography(HPLC). Besides, chromatographic column Feinigen XPeonyx C18(250 mm×4.6 mm, 5 μm), mobile phase was used, gradient elution was carried out with acetonitrile-0.1% phosphoric acid aqueous solution, the detection wavelength was 236 nm, the flow rate was 1.0 mL/min, the column temperature was 30 ℃, and the injection volume was 10 μL. [Results] The thin-layer chromatography of P. scandens and A. carvifolia reference materials showed clear spots, good separation effect, strong specificity, and no interference in the limit control; paederosidic acid showed a good linear relationship in the range of 0.65-9.75 μg(R2=0.999 6), the average sample recovery rate was 99.72%(RSD=2.52%). [Conclusions] The qualitative and quantitative methods established in this experiment are simple, reproducible, and the results are accurate and reliable, and can be applied as a quality control method for children antipyretic lotions.

【基金】 Supported by Open project of Guangxi Zhuang and Yao Pharmaceutical Engineering Technology Research Center(KJT1900105);Key Research and Development Program of Department of Science and Technology of Guangxi Zhuang Autonomous Region(Guangxi Science and Technology AB19110003)
【所属期刊栏目】 Clinical Application (2019年06期)
  • 【DOI】10.19600/j.cnki.issn2152-3924.2019.06.023
  • 【分类号】R286.0
  • 【下载频次】2
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