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Research Progress in the Regulation of Tumor Cells and Tumor Stem Cells at Multiple Targets by Antrodia camphorata

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【作者】 Qingfa CHENYan XUXiaodong SHIChuanfei WEIHaitao XIERuxi LV

【Author】 Qingfa CHEN;Yan XU;Xiaodong SHI;Chuanfei WEI;Haitao XIE;Ruxi LV;The Institute of Tissue Engineering and Regenerative Medicine, Liaocheng People’s Hospital;Department of Pain, Liaocheng People’s Hospital;Department of Neurosurgery, Weifang Yidu Central Hospital;Centre for Research, Xiankangda Biotech Corporation;Department of Gastroenterology, Liaocheng People’s Hospital;

【通讯作者】 Ruxi LV;

【机构】 The Institute of Tissue Engineering and Regenerative Medicine, Liaocheng People’s HospitalDepartment of Pain, Liaocheng People’s HospitalDepartment of Neurosurgery, Weifang Yidu Central HospitalCentre for Research, Xiankangda Biotech CorporationDepartment of Gastroenterology, Liaocheng People’s Hospital

【摘要】 Extensive in vitro and in vivo research reveals multiple intracellular molecular targets of Antrodia camphorata, and these targets affect growth, apoptosis, angiogenesis, invasion and metastasis of cells. These targets include tumor suppressor, cell cycle regulator, transcription factor, angiogenesis and metastasis factor, apoptosis and survival regulator, etc. Additionally, more and more attention has been paid to the molecular mechanism of A. camphorata on the regulation of tumor stem cells. Meanwhile, there is evidence that the immunoregulation of A. camphorata is enhanced, which may lead cell cycle arrest or apoptosis. In this paper, molecular mechanism of tumor cells and tumor stem cells regulated at multiple targets by A. camphorata in vitro and in vivo in the past decade is summarized.

【基金】 Supported by Shandong Medical and Health Development Plan (2018WS423)
【所属期刊栏目】 Review (2020年03期)
  • 【DOI】10.19600/j.cnki.issn2152-3924.2020.03.002
  • 【分类号】R285.5
  • 【下载频次】3
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