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Effects of Dachengqi Decoctions Made from Raw Rhubarb and Vinegar-processed Rhubarb on Levels of Endotoxin, NO and TNF-α in Serum

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【作者】 Wen ZHONGZujie QINJiangcun WEIZhen XIEXiumei MAXianyi SHIFengxian ZHAOQian HAN

【Author】 Wen ZHONG;Zujie QIN;Jiangcun WEI;Zhen XIE;Xiumei MA;Xianyi SHI;Fengxian ZHAO;Qian HAN;Guangxi International Zhuang Medicine Hospital;Guangxi University of Chinese Medicine;

【通讯作者】 Jiangcun WEI;

【机构】 Guangxi International Zhuang Medicine HospitalGuangxi University of Chinese Medicine

【摘要】 [Objectives] The effects of Dachengqi decoctions made from raw rhubarb and vinegar-processed rhubarb on serum endotoxin, NO and TNF-α levels were investigated. [Methods] Total 105 mice were randomly divided into Dachengqi decoction made from raw rhubarb groups(6, 10 g/kg), Dachengqi decoction made from vinegar-processed rhubarb groups(6, 10 g/kg), positive control group, blank control group and model group. After administration at a dose of 20 mL/kg, the levels of endotoxin, NO and TNF-α in serum were determined. The effects of Dachengqi decoctions made from raw rhubarb and vinegar-processed rhubarb on serum endotoxin, NO and TNF-α levels in mice were compared. [Results] Dachengqi decoctions made from raw rhubarb and vinegar-processed rhubarb both increased the NO level and reduced the endotoxin and TNF-α levels in serum of ABP mice. [Conclusions] Dachengqi decoctions made from raw rhubarb and vinegar-processed rhubarb have different effects on endotoxin, NO and TNF-α contents. These changes correspond to the effects of Dachengqi Decoctions made from raw rhubarb and vinegar-processed rhubarb. The change in the content of rhubarb anthraquinones has a certain effect on the efficacy of Dachengqi decoction.

【基金】 Supported by National Natural Science Foundation of China(No.81360524);Youth Foundation of Guangxi University of Chinese Medicine(No.2019QN036);Project for Improving Basic Scientific Research Ability of Young and Middle-aged Teachers in Colleges and Universities of Guangxi in 2019(No.2019KY0341);Traditional Chinese Medicine Scientific Research Laboratory(Grade III) of National Administration of Traditional Chinese Medicine:Laboratory of Chinese(Zhuang) Medicine Chemical and Quality Analysis(Guo Zhong Yi Yao Fa 2009[21])
【所属期刊栏目】 Animal Experiment (2020年03期)
  • 【DOI】10.19600/j.cnki.issn2152-3924.2020.03.019
  • 【分类号】R285.5
  • 【下载频次】8
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