节点文献

MiR-125a-5p is Upregulated in Plasma of Residents from An Electronic Waste Recycling Site

免费订阅

【作者】 Li RanQiu XinghuaYang QiaoyunLi KeqiuLi Guang

【Author】 Li Ran;Qiu Xinghua;Yang Qiaoyun;Li Keqiu;Li Guang;State Key Joint Laboratory for Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering and Center for Environment and Health, Peking University;Basic Medical College, Tianjin Medical University;

【机构】 State Key Joint Laboratory for Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering and Center for Environment and Health, Peking UniversityBasic Medical College, Tianjin Medical University

【摘要】 The mechanism of health effects caused by organohalogen pollutants, e.g., toxins from electronic waste(e-waste), is poorly understood. We supposed that micro RNAs(mi RNAs), an important post-transcriptional regulator, could play a role in this process. In this study, fasting peripheral blood samples were collected from residents living at an e-waste site in northern China and a nearby reference population. Concentrations of e-waste related organohalogen pollutants in plasma from the exposure group were higher than the corresponding measurement in the reference group. Correspondingly, sixty mi RNAs in plasma showed > 2-fold change between the two groups in microarray analysis. Among them, mi R-125a-5p was confirmed to be upregulated by q RT-PCR and its validated targets were enriched in responses to xenobiotics and cancer related pathways. Furthermore, significant positive correlations were found between levels of mi R-125a-5p in plasma and reactive oxygen species(ROS) in polymorphonuclear neutrophil leukocytes(P < 0.05). These evidences suggested oxidative stress might be an intermediate between e-waste related POPs exposure and alteration of plasma mi RNA.

【基金】 National Natural Science Foundation of China(21322705,41121004,21190051,and 21177091)
【所属期刊栏目】 专论 (2016年02期)
  • 【分类号】X503.1;R114
  • 【下载频次】18
节点文献中: 

本文链接的文献网络图示:

浏览历史:
下载历史: