Synthesis,Crystal Structure,Thermal Stability and Anti-tumor Activity In Vitro of Bis（tricyclohexyltin） Pimelicarboxylate

朱小明邝代治冯泳兰张复兴庾江喜蒋伍玖张志坚

Department of Chemistry and Material Science,Hengyang Normal University Key Laboratory of Functional Organometallic Materials of Hengyang Normal University,College of Hunan Province Department of Life Science,Hengyang Normal University

摘要：Bis（tricyclohexyltin） pimelicarboxylate,[（CH2）5（CO2SnCy3）2]（1）,has been synthesized by the reaction of tricyclohexyltin hydroxide with pimelic acid and characterized by means of IR,1H and 13 C NMR,elemental analysis and X-ray diffraction.Complex 1 crystallizes in triclinic space group P1 with a=11.569（3）,b=12.0419（2）,c=17.3988（4） ?,α=81.4310（10）,β=79.8270（10）,γ=69.7060（10）o,V=2227.60（9） ?3,Z=2,C43H76O4Sn2,Mr=894.42,Dc=1.333 g·cm-3,μ=1.157 mm-1,F（000）=932,GOOF=1.339,the final R=0.0452 and w R=0.1333 for 6709 observed reflections（I ＞ 2σ（I））.Complex 1 shows discrete dimeric structures and the tin atoms have a distorted tetrahedral geometry.The 1D chain structure of complex 1 is formed by intermolecular Sn···O interactions.Complex 1 displays good thermal stability under 553 K and has selective antibacterial property.Complex 1 is strong in vitro anti-tumor activity against five human tumor cell lines,Colo205,Hep G2,MCF-7,Hela and NCI-H460,and is significantly higher than that in the clinical use of carboplatin.

基金资助：

Supported by the Natural Science Foundation of Hunan Province（No.13JJ3112）； Scientific＆Technological Projects of Hunan Province（Nos.2013TZ2025,2014NK3086,2014FJ3060）； the Open Fund Project of Key Laboratory of Functional Organometallic Materials of Hengyang Normal University（Nos.13K105,14K014,13K01-05,GN14K01）； Aid Programs for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province,the Key Discipline of Hunan Province,the Scientific Research Fund of Hunan Provincial Education Department of China（No.15C0199,15C0200,14C0171,14C0168）； the Science Foundation of Hengyang Normal University of China（No.12C45）；