Synthesis,Crystal Structure and Antitumor Activity of a New Zn(Ⅱ) Complex Based on N-Acetyl-L-phenylalanine and 1,10-Phenanthroline
台夕市王欣游海英
College of Chemistry and Chemical Engineering,Weifang UniversityDepartment of Chemistry,Qinghai Normal UniversityWeifang University of Science and Technology
摘要:A new Zn(Ⅱ) complex, [Zn(L)2(phen)(H2O)](1, HL = N-acetyl-L-phenylalanine, phen = 1,10-phenanthroline) has been synthesized and characterized by elemental analysis, IR and X-ray single-crystal diffraction analysis. The Zn(Ⅱ) complex belongs to monoclinic, space group P21 with a = 12.6749(13), b = 5.5965(6), c = 22.985(2) ?, β = 104.296(2)°, V = 1580.0(3) ?~3, Z = 2, Mr = 676.02, Dc = 1.421 μg·m-3, μ = 0.833 mm-1, F(000) = 704, and the final R = 0.0460, wR = 0.0899 for 4422 observed reflections with I > 2σ(I). The molecules form a 1D chained structure by hydrogen bonds. The antitumor activities of Zn(Ⅱ) complex against human hepatoma SMMC-7721 cells, human lung adenocarcinoma A549 cells and human colon carcinoma WiDr cells have also been investigated.
基金资助:
supported by the National Natural Science Foundation of China(No.21171132); the Project of Shandong Province Higher Educational Science and Technology Program(J14LC01); Science Foundation of Weifang;
- DOI:
10.14102/j.cnki.0254-5861.2011-0910
- 专辑:
- 专题:
- 分类号:
O641.4
引文网络
- 参考文献
- 引证文献
- 共引文献
- 同被引文献
- 二级参考文献
- 二级引证文献
相关推荐
- 相似文献
- 读者推荐
- 相关基金文献
- 关联作者
- 相关视频