Synthesis,Crystal Structure and Antitumor Activity of a New Zn（Ⅱ） Complex Based on N-Acetyl-L-phenylalanine and 1,10-Phenanthroline

台夕市王欣游海英

College of Chemistry and Chemical Engineering,Weifang UniversityDepartment of Chemistry,Qinghai Normal UniversityWeifang University of Science and Technology

摘要：A new Zn（Ⅱ） complex, [Zn（L）₂（phen）（H₂O）]（1, HL = N-acetyl-L-phenylalanine, phen = 1,10-phenanthroline） has been synthesized and characterized by elemental analysis, IR and X-ray single-crystal diffraction analysis. The Zn（Ⅱ） complex belongs to monoclinic, space group P21 with a = 12.6749（13）, b = 5.5965（6）, c = 22.985（2） ?, β = 104.296（2）°, V = 1580.0（3） ?³, Z = 2, M_r = 676.02, D_c = 1.421 μg·m^-3, μ = 0.833 mm^-1, F（000） = 704, and the final R = 0.0460, wR = 0.0899 for 4422 observed reflections with I > 2σ（I）. The molecules form a 1D chained structure by hydrogen bonds. The antitumor activities of Zn（Ⅱ） complex against human hepatoma SMMC-7721 cells, human lung adenocarcinoma A549 cells and human colon carcinoma WiDr cells have also been investigated.

基金资助：

supported by the National Natural Science Foundation of China（No.21171132）； the Project of Shandong Province Higher Educational Science and Technology Program（J14LC01）； Science Foundation of Weifang；