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Synthesis,Crystal Structure and Antifungal Activity of 2-((2-Fluorobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole

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【作者】 孙国香石延霞翟志文孙召慧翁建全谭成侠刘幸海李宝聚

【Author】 SUN Guo-Xiang;SHI Yan-Xia;ZHAI Zhi-Wen;SUN Zhao-Hui;WENG Jian-Quan;TAN Cheng-Xia;LIU Xing-Hai;LI Bao-Ju;School of Chemistry and Chemical Engineering,Yancheng Institute of Technology;Institute of Vegetables and Flowers,Chinese Academy of Agricultural Sciences;College of Chemical Engineering,Zhejiang University of Technology;

【机构】 School of Chemistry and Chemical Engineering,Yancheng Institute of TechnologyInstitute of Vegetables and Flowers,Chinese Academy of Agricultural SciencesCollege of Chemical Engineering,Zhejiang University of Technology

【摘要】 The title compound 2-((2-fluorobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole(C14H10FN3OS) was synthesized,and its structure was confirmed by 1H NMR,MS,elemental analyses and X-ray diffraction. It crystallizes in the monoclinic system,space group P21/n with a = 11.541(16),b = 8.226(12),c = 13.683(19) ?,β = 94.872(17)o,V = 1294(3) ?3,Z = 4 and R = 0.0648 for 2198 observed reflections with I > 2σ(I). The preliminary biological test shows that the title compound has good activity against Pythium ultimum with inhibitory to be 100%.

【基金】 funded by the Natural Science Foundation of Zhejiang Province(No.LY16C140007);the program of Science and Technology of Jiangsu Province(BY2014108-14)
【所属期刊栏目】 medicinal structural chemistry (2016年12期)
  • 【DOI】10.14102/j.cnki.0254-5861.2011-1352
  • 【分类号】O626
  • 【被引频次】3
  • 【下载频次】43
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